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Year : 2017  |  Volume : 1  |  Issue : 1  |  Page : 13-17

Epigenetic Modification in Oocyte and Preimplantation Embryonic Development


1 Department of Obstetrics and Gynecology, Peking University Third Hospital; Key Laboratory of Assisted Reproduction, Ministry of Education; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China
2 Department of Obstetrics and Gynecology, Peking University Third Hospital; Key Laboratory of Assisted Reproduction, Ministry of Education; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191; Beijing Advanced Innovation Center for Genomics, Beijing 100871; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China

Correspondence Address:
Jie Qiao
Department of Obstetrics and Gynecology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.210694

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DNA methylation and histone modification are two of the most characterized epigenetic modifications. With advanced detecting techniques, particularly single-cell sequencing, we can dissect epigenomic patterns and their regulatory roles in the growth and differentiation of gametes and early embryos in animals and humans. Assisted reproductive technology (ART) procedures have been shown to influence the methylation of certain genes. Aberrant epigenetic regulation may cause several developmental disorders and clinical diseases. Here, we describe some concepts in epigenetics and review recent researches on DNA methylation and the histone modification profile and their regulatory roles during early embryo development. We also summarize the recent progress in understanding the imprinting disorders associated with ART procedures.


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