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REVIEW ARTICLE
Year : 2017  |  Volume : 1  |  Issue : 1  |  Page : 23-29

Biological Functions and Research Methods of Long Noncoding RNAs


1 Department of Biochemistry and Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai 200030, China
2 Department of Biochemistry and Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University; Research Center for Birth Defects, Fudan University, Shanghai 200030, China

Correspondence Address:
Duan Ma
Department of Biochemistry and Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai 200030
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.210697

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Long noncoding RNAs (lncRNAs) are functional RNA molecules which are longer than 200 nucleotides in length that do not encode proteins; instead, they regulate target gene expression at transcriptional, posttranscriptional, and epigenetic levels. LncRNAs play important roles in various biological processes such as dosage compensation, genomic imprinting, cell cycle regulation, and cell differentiation. Although their characterizations have been relatively straightforward with recent advances in modern biology, the functions of lncRNAs are largely unknown. Herein, we discuss the biological functions and research methods of lncRNAs.


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