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REVIEW ARTICLE
Year : 2017  |  Volume : 1  |  Issue : 1  |  Page : 30-35

Application of Single-cell Sequencing Technologies in Reproductive Medicine


1 Department of Obstetrics and Gynecology, Peking University Third Hospital; Key Laboratory of Assisted Reproduction, Ministry of Education; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China
2 Department of Obstetrics and Gynecology, Peking University Third Hospital; Key Laboratory of Assisted Reproduction, Ministry of Education; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology; Beijing Advanced Innovation Center for Genomics; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China

Correspondence Address:
Jie Qiao
Department of Obstetrics and Gynecology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.210691

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We have recently witnessed the rapid development of various single-cell sequencing technologies. Pioneering single cell assays are now available for the profiling of genome, epigenome, and transcriptome. Single-cell sequencing technologies provide multi-dimensional information on early embryonic development in humans and in clinical contexts where specimens are scarce. Here, we review several available techniques and their applications in reproductive medicine. Continuing development of multimodal single-cell sequencing measurement techniques in combination with multi-omics assays will provide comprehensive profiles of an individual cell and lead to the targeted therapy for reproductive disorders and infertility.


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