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REVIEW ARTICLE
Year : 2017  |  Volume : 1  |  Issue : 1  |  Page : 36-44

Immune Regulation at Maternal-fetal Interface in Early Pregnancy


1 Laboratory for Reproductive Immunology, Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China
2 Laboratory for Reproductive Immunology, Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases; Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011, China

Correspondence Address:
Da-Jin Li
Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Zhao Zhou Road 413, Shanghai 200011
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.210695

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Decidual immune cells (DICs), including T-cells, regulatory T-cells, macrophages/dendritic cells, natural killer cells, and neutrophils, are resident at the maternal–fetal interface, and play vital roles in regulating trophoblast migration, decidual angiogenesis, immune tolerance, placentation, and decidualization during the early pregnancy. Extensive researches have revealed that these maternal DICs cooperated with each other, or with maternal decidual stromal cells, or with fetal-derived trophoblasts, and further formed a special maternal-fetal cross talk at the maternal-fetal interface, which was essential for the construction and maintenance of physiological pregnancy. Once aberrant cross talk and immune regulation arise, many pregnancy complications will inevitably occur, such as spontaneous abortion, intrauterine growth restriction(IUGR), preeclampsia (PE), and preterm birth. Here, we reviewed how critical immune cells are either enriched or excluded from the decidua, how their function is regulated within the decidua, and how they variously contribute to pregnancy success or failure.


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