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REVIEW ARTICLE
Year : 2017  |  Volume : 1  |  Issue : 1  |  Page : 45-54

Mitochondrial Dysfunction and Age - related Oocyte Quality


1 Center for Reproductive Medicine, the 10th People's Hospital of Tongjin University, Shanghai 200072, China
2 Center for Reproductive Medicine, the 10th People's Hospital of Tongjin University, Shanghai 200072, China; Department of Obstetrics and Gynecology, McGill University, Montreal, Canada

Correspondence Address:
Ri-Cheng Chian
Center for Reproductive Medicine, The 10th People's Hospital of Tongjin University, Shanghai, China Department of Obstetrics and Gynecology, McGill University, Montreal

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.210693

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Fertility disorders have become a growing problem worldwide. It is well known that female fertility decreases with age, previous studies suggested that the age-related decline in female fertility potential was largely due to decrease in oocyte quality and mitochondrial dysfunction. Mitochondria play a crucial role during the process of oocyte maturation. Mitochondrial genetic, numerical and structural defects occur in oocyte aging process, mitochondrial abnormalities are believed to contribute to age-related infertility. Improvement of the mitochondrial function can lead to better fertility outcomes, and application of mitochondria replacement strategy or mitochondrial transfer to age-related infertility will be possible in the future. This review paper, we are trying to discuss current understanding about age-related changes in oocyte quality and mitochondrial dysfunction.


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