• Users Online: 114
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2018  |  Volume : 2  |  Issue : 2  |  Page : 100-104

Clinical Results of In Vitro Fertilization or Intracytoplasmic Sperm Injection Treatments in Women Aged 40 Years and above


Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Correspondence Address:
Chun-Ying Su
Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.242754

Rights and Permissions

Objective: The study was designed to estimate the live birth rate (LBR) and cumulative LBR (CLBR) in patients aged ≥40 years undergoing in vitro fertilization or intracytoplasmic sperm injection treatments during their first and multiple ovarian stimulation cycle(s). Methods: A total of 697 advanced women underwent 1,293 treatment cycles, and 973 fresh embryo transfers were performed. The LBR and CLBR were analyzed with respect to an increase in the maternal age by every year. Results: A declining trend in LBR and CLBR of the first cycle was seen with an increase in maternal age. The LBR in women aged 40 years was significantly higher than that in women aged ≥44 years (18.39% and 4.39%, respectively); the CLBR in women aged 40 years was also significantly higher than that in women aged 42, 43, and ≥44 years (22.40%, 9.09%, 9.09%, and 4.80%, respectively). However, there was no significant difference (P > 0.05) in the rate of miscarriage among all groups. For those who underwent multiple cycles, the number of live-born babies decreased rapidly after three ovarian stimulation cycles; the LBR in patients aged 40 years was significantly higher than that in patients aged 42 years and ≥44 years (15.24%, 5.20%, and 4.49%, respectively), and the CLBR in patients aged 40–41 years was significantly higher than that in patients aged ≥42 years. The CLBR in all groups gradually plateaued after three cycles; women aged 40–41 years achieved relatively reasonable CLBR, while the CLBR was <10% in women aged ≥42 years. Conclusions: Women aged 40–41 years had a low but acceptable outcome in the first three ovarian stimulation cycles. The success rate quickly decreased, and for women aged ≥42 years, the decision to continue after three ovarian stimulation cycles should be made cautiously.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed262    
    Printed26    
    Emailed0    
    PDF Downloaded43    
    Comments [Add]    

Recommend this journal