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REVIEW ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 2  |  Page : 110-116

Indoleamine 2,3-dioxygenase in endometriosis


1 Laboratory for Reproductive Immunology, Insitute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, China
2 Laboratory for Reproductive Immunology, Insitute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Shanghai 200080; Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Shanghai 200011; Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai 230032, China

Correspondence Address:
Dr. Ming-Qing Li
Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Lane1326, Pingliang Road, Shanghai 200080
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.262391

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Endometriosis (EMS) is a chronic inflammatory and estrogen-dependent gynecological disease characterized by the presence of endometrial tissue outside the uterine cavity. Although it is a benign disease, EMS is tumor-like in several aspects, which include unrestrained growth, decreased apoptosis, and aggressive invasion. EMS involves endocrine disorders and immunological factors. Indoleamine 2,3-dioxygenase (IDO) is an intracellular enzyme that catalyzes the initial and rate-limiting step of the metabolism of tryptophan. IDO is a potential candidate facilitating EMS development. Increased IDO expression in both eutopic and ectopic endometria of women with EMS is biologically important in aspects, which include regulation of endometrial stromal cell function and modulation of adjacent local immunocytes to generate a supportive microenvironment. In turn, the expression of IDO can be regulated by the complex endocrine-immune microenvironment networks in endometrial lesions. Here, we systematically review the roles of IDO in EMS to explore its pathological implications and treatment potential.


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