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ORIGINAL ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 2  |  Page : 97-101

Analysis of clinicopathologic classification features of hydatidiform mole misdiagnosed as missed abortion preoperatively


1 Department of Family Planning, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
2 Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
3 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China

Correspondence Address:
Prof. Jin Zhu
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Shanghai 200011
China
Prof. Xiao-Ying Yao
Department of Family Planning, Obstetrics and Gynecology Hospital of Fudan University, No. 419, Fangxie Road, Shanghai 200011
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.262393

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Objective: To analyze clinicopathologic classification features of the cases that were diagnosed as missed abortion preoperatively but turn out to be hydatidiform mole (HM) postoperatively. Methods: A retrospective analysis was conducted on the patients who had a missed abortion in our hospital from 2017 to 2018. Clinical and pathological characteristics of different types of HMs were observed. Diagnostic value of karyotype in HM was discussed based on the karyotype analysis of villi chromosome. Results: A total of 278 (11.2%) HM patients were misdiagnosed as missed abortion. Naked-eye detection rate of HM was 26.61%, and sensitivity of transvaginal ultrasound on HM was 7.91%. One hundred and forty-seven (52.88%) HM cases could not be genotyped via pathological hematoxylin and eosin (HE) staining. 70 HM patients underwent P57 immunohistochemistry, which had guiding significance to the classification. In addition, the karyotype diagnosis of the tissues from 15 cases basically matched their P57 classifications. Conclusions: P57 should be listed as a routine test in hydatidiform pathological examination at the same time of HE staining, and what's more, P57 expression is consistent with genotyping, which should be recommended for the patients with HM if observed by naked eye.


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