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REVIEW ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 3  |  Page : 170-176

Role of oxidative stress and antioxidant therapies in endometriosis


Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China

Correspondence Address:
Xin-Mei Zhang
Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, No. 1 Xueshi Road, Hangzhou 310006
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.268154

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Endometriosis (EMS) is a common gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity. It is commonly associated with pelvic pain and infertility. The exact pathogenesis remains unclear and many hypotheses have been suggested. In recent years, accumulating evidence indicates that oxidative stress (OS) plays a role in the development of EMS. The treatment of EMS remains a challenge. Antioxidant therapies for effective management of reactive oxygen species and inflammation have generated considerable research interest. Antioxidant agents such as Vitamins C and E, resveratrol, curcumin, melatonin, epigallocatechin-3-gallate, and others have been studied for the treatment of EMS. This review presents the role of OS in pathophysiology of EMS and the antioxidant therapies in its management.


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