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REVIEW ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 4  |  Page : 243-246

Advances on the metabolism of cohesin in age-related chromosomal aneuploidy


Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China

Correspondence Address:
Bin Zhang
Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, 419 Fangxie Road, Shanghai 200011
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.274547

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Age-related chromosomal aneuploidy is associated with the reduction of cohesin in meiosis. There are many complicated factors affecting the metabolism of cohesion, including the hyperactive separase, abnormal Shugoshin protein degradation, oxidative damage, increased intracellular pH in oocytes, abnormal metabolism of spindle assembly checkpoint, anaphase-promoting complex, and age-related reproductive hormones, which are summarized in the review.


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