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REVIEW ARTICLE
Year : 2020  |  Volume : 4  |  Issue : 1  |  Page : 53-59

Innate lymphoid cells in normal pregnancy and pregnancy-Related diseases


1 Laboratory for Reproductive Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
2 Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
3 Laboratory for Reproductive Immunology, Institute of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University; Laboratory for Reproductive Immunology, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai 230032, China

Correspondence Address:
Ming-Qing Li
Laboratory for Reproductive Immunology, Institute of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Lane 1326 Pingliang Road, Shanghai 200082
China
Wei-Rong Gu
Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, 419 Fangxie Road, Shanghai 200011
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.281858

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Innate lymphoid cells (ILCs) are a group of lymphocytes without diversified antigen receptors encoded by gene rearrangement on T and B cells. ILCs, which are tissue-resident innate immune cells, expressed particularly in the mucosa or the barrier surface, contribute to the formation of lymphoid organs, the maintenance of tissue homeostasis, and the regulation of antimicrobial defenses. It has been recently reported that ILCs were enriched at the maternal–fetal interface. During a successful pregnancy, the maternal immune system must tolerate a fetus as an allograft. With the new defined of ILCs, a number of studies have shown that three types of ILCs are involved in embryonic development and pregnancy maintenance as well as the occurrence and development of pregnancy-related complications. This article reviews the types and roles of ILCs in normal pregnancy and pregnancy-related diseases.


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