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EXPERT REVIEW
Year : 2020  |  Volume : 4  |  Issue : 1  |  Page : 7-10

Single-cell RNA expression profiling of ACE2 and AXL in the human maternal–Fetal interface


Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China

Correspondence Address:
Li-Ping Jin
Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204
China
Tao Duan
Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.278679

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2019 novel coronavirus disease has resulted in thousands of critically ill patients in China, which is a serious threat to people's life and health. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) was reported to share the same receptor, angiotensin-converting enzyme 2 (ACE2), with SARS-CoV. Here, based on the public single-cell RNA-sequencing database, we analyzed the mRNA expression profile of putative receptor ACE2 and AXL receptor tyrosine kinase (AXL) in the early maternal–fetal interface. The result indicates that the ACE2 has very low expression in the different cell types of early maternal–fetal interface, except slightly high in decidual perivascular cells cluster 1 (PV1). Interestingly, we found that the Zika virus (ZIKV) receptor AXL expression is concentrated in perivascular cells and stromal cells, indicating that there are relatively more AXL-expressing cells in the early maternal–fetal interface. This study provides a possible infection route and mechanism for the SARS-CoV-2- or ZIKV-infected mother-to-fetus transmission disease, which could be informative for future therapeutic strategy development.


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