Reproductive and Developmental Medicine

REVIEW ARTICLE
Year
: 2017  |  Volume : 1  |  Issue : 1  |  Page : 45--54

Mitochondrial Dysfunction and Age - related Oocyte Quality


Han Li1, Ri-Cheng Chian2 
1 Center for Reproductive Medicine, the 10th People's Hospital of Tongjin University, Shanghai 200072, China
2 Center for Reproductive Medicine, the 10th People's Hospital of Tongjin University, Shanghai 200072, China; Department of Obstetrics and Gynecology, McGill University, Montreal, Canada

Correspondence Address:
Ri-Cheng Chian
Center for Reproductive Medicine, The 10th People's Hospital of Tongjin University, Shanghai, China Department of Obstetrics and Gynecology, McGill University, Montreal

Fertility disorders have become a growing problem worldwide. It is well known that female fertility decreases with age, previous studies suggested that the age-related decline in female fertility potential was largely due to decrease in oocyte quality and mitochondrial dysfunction. Mitochondria play a crucial role during the process of oocyte maturation. Mitochondrial genetic, numerical and structural defects occur in oocyte aging process, mitochondrial abnormalities are believed to contribute to age-related infertility. Improvement of the mitochondrial function can lead to better fertility outcomes, and application of mitochondria replacement strategy or mitochondrial transfer to age-related infertility will be possible in the future. This review paper, we are trying to discuss current understanding about age-related changes in oocyte quality and mitochondrial dysfunction.


How to cite this article:
Li H, Chian RC. Mitochondrial Dysfunction and Age - related Oocyte Quality.Reprod Dev Med 2017;1:45-54


How to cite this URL:
Li H, Chian RC. Mitochondrial Dysfunction and Age - related Oocyte Quality. Reprod Dev Med [serial online] 2017 [cited 2020 Jul 9 ];1:45-54
Available from: http://www.repdevmed.org/article.asp?issn=2096-2924;year=2017;volume=1;issue=1;spage=45;epage=54;aulast=Li;type=0