Reproductive and Developmental Medicine

REVIEW ARTICLE
Year
: 2019  |  Volume : 3  |  Issue : 4  |  Page : 247--251

Endometriosis pathoetiology: The role of micrornas in the dysregulation of endometrial functions


Jiahui Zhang1, Isabelle Baptista2, Ping Xia3, Bhuchitra Singh4 
1 Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA
2 Johns Hopkins University, Baltimore, MD 21205, USA
3 Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
4 Department of Gynecology and Obstetrics, Division of Reproductive Sciences and Women's Health Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Correspondence Address:
Bhuchitra Singh
Department of Gynecology and Obstetrics, Division of Reproductive Sciences and Women's Health Research, Johns Hopkins School of Medicine, 720 Rutland Avenue, Ross Research Building, Room No. 624, Baltimore, MD 21205
USA

Endometriosis is a common gynecological disorder characterized by pelvic pain, heavy menstruation, and infertility. The clinical diagnosis of endometriosis is often delayed 8–10 years after the onset of symptoms due to the lack of an effective and reliable noninvasive diagnostic method. In recent years, a number of research studies have reported using microRNAs (miRNAs) as potential noninvasive biomarkers for diagnosing endometriosis. Because miRNAs regulate gene expression, the differential expression of miRNAs in endometriosis patients also provides insight on dysregulated gene expressions in the pathogenesis of endometriosis. In this review, a number of global profiling studies (published through July 2019) that investigated the differential expression of miRNAs in endometriosis were identified. Based on these findings, the role of miRNAs in the pathogenesis of endometriosis, particularly with regard to the dysregulation of endometrial functions, cell cycle regulation, proliferation of endometrial stromal cells, and angiogenesis, was discussed. The potential of these miRNAs as noninvasive diagnostic biomarkers of endometriosis was also discussed.


How to cite this article:
Zhang J, Baptista I, Xia P, Singh B. Endometriosis pathoetiology: The role of micrornas in the dysregulation of endometrial functions.Reprod Dev Med 2019;3:247-251


How to cite this URL:
Zhang J, Baptista I, Xia P, Singh B. Endometriosis pathoetiology: The role of micrornas in the dysregulation of endometrial functions. Reprod Dev Med [serial online] 2019 [cited 2020 Feb 27 ];3:247-251
Available from: http://www.repdevmed.org/article.asp?issn=2096-2924;year=2019;volume=3;issue=4;spage=247;epage=251;aulast=Zhang;type=0