Figure 2: Gm48853 mutation resulted in severe embryonic growth retardation. (A) Photomicrographs of Gm48853+/+embryos (a and d), Gm48853+/PBembryos (b and e), Gm48853PB/PBembryos (c and f) at E9.5 (a-c) and E10.5 (d-f). (B) H and E-stained paraffin sections of WT and Gm48853PB/PBembryos at E10.5. (C and D) Images of embryonal cryosections with the indicated genotypes for the EdU assay (C) and TUNEL assay (D). High-magnification images of the cropped region in (B) are shown beneath each panel. Images are representative sections from at least 3 embryos per group. EdU: 5-Ethynyl-2'-deoxyuridine; TUNEL: Terminal deoxynucleotidyl transferase deoxy-UTP-nick-end labeling; H and E: Hematoxylin and eosin.