• Users Online: 257
  • Print this page
  • Email this page
REVIEW ARTICLE
Year : 2021  |  Volume : 5  |  Issue : 1  |  Page : 55-62

Clinical application potential of umbilical cord mesenchymal stem cells in chemotherapeutic ovarian failure


1 Department of Gynecological Endocrinology, The Fourth Hospital of Shijiazhuang, Shijiazhuang 050000, China
2 2Department of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
3 Department of Neonatology, The Fourth Hospital of Shijiazhuang, Shijiazhuang 050000, China

Correspondence Address:
Xue-Lei Ding
Department of Gynecological Endocrinology, The Fourth Hospital of Shijiazhuang, 206 Zhongshan East Road, Shijiazhuang 050000
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.313685

Rights and Permissions

Chemotherapy is often used for female malignancies, but it can increase the risk of premature ovarian failure in women of reproductive age through different mechanisms. Therefore, how to protect ovarian function and preserve fertility has attracted great attention of oncologists and gynecologists. Recently, umbilical cord mesenchymal stem cells (UCMSCs) have been extensively studied in the field of regenerative medicine. Compared with mesenchymal stem cells (MSCs) from other sources, UCMSCs have a broader application potential due to their properties of lower immunogenicity, fewer ethical issues, and non-invasive collection. Paracrine is one of the most important therapeutic mechanisms of UCMSCs, which can exert anti-inflammatory, anti-fibrosis, anti-oxidative stress, immune regulation, and other therapeutic effects. Studies in animal models have shown that UCMSCs can restore ovarian function after chemotherapy injury. However, most of the relevant researches are still in the preclinical stage. In this article, the mechanism of chemotherapy-induced ovarian failure will be overviewed, and the clinical application potential of UCMSCs in chemotherapeutic ovarian injury will be discussed.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed232    
    Printed0    
    Emailed0    
    PDF Downloaded31    
    Comments [Add]    

Recommend this journal