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Year : 2021  |  Volume : 5  |  Issue : 1  |  Page : 55-62

Clinical application potential of umbilical cord mesenchymal stem cells in chemotherapeutic ovarian failure

1 Department of Gynecological Endocrinology, The Fourth Hospital of Shijiazhuang, Shijiazhuang 050000, China
2 2Department of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
3 Department of Neonatology, The Fourth Hospital of Shijiazhuang, Shijiazhuang 050000, China

Correspondence Address:
Xue-Lei Ding
Department of Gynecological Endocrinology, The Fourth Hospital of Shijiazhuang, 206 Zhongshan East Road, Shijiazhuang 050000
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2096-2924.313685

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Chemotherapy is often used for female malignancies, but it can increase the risk of premature ovarian failure in women of reproductive age through different mechanisms. Therefore, how to protect ovarian function and preserve fertility has attracted great attention of oncologists and gynecologists. Recently, umbilical cord mesenchymal stem cells (UCMSCs) have been extensively studied in the field of regenerative medicine. Compared with mesenchymal stem cells (MSCs) from other sources, UCMSCs have a broader application potential due to their properties of lower immunogenicity, fewer ethical issues, and non-invasive collection. Paracrine is one of the most important therapeutic mechanisms of UCMSCs, which can exert anti-inflammatory, anti-fibrosis, anti-oxidative stress, immune regulation, and other therapeutic effects. Studies in animal models have shown that UCMSCs can restore ovarian function after chemotherapy injury. However, most of the relevant researches are still in the preclinical stage. In this article, the mechanism of chemotherapy-induced ovarian failure will be overviewed, and the clinical application potential of UCMSCs in chemotherapeutic ovarian injury will be discussed.

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