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ORIGINAL ARTICLE
Year : 2021  |  Volume : 5  |  Issue : 2  |  Page : 71-80

Long-term androgen-induced nonalcoholic fatty liver disease in a polycystic ovary syndrome mouse model is related to mitochondrial dysfunction


1 Department of Integrative Medicine and Neurobiology, State Key Lab of Medical Neurobiology, Institute of Acupuncture Research (WHO Collaborating Center for Traditional Medicine), Institute of Integrative Medicine, Institute of Brain Science, School of Basic Medical Sciences, Fudan University, Shanghai 200032; Department of Obstetrics and Gynecology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2 Department of Integrative Medicine and Neurobiology, State Key Lab of Medical Neurobiology, Institute of Acupuncture Research (WHO Collaborating Center for Traditional Medicine), Institute of Integrative Medicine, Institute of Brain Science, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
3 Nursing Department, the International Peace Maternal and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China
4 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
5 Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Gothenburg 40530, Sweden

Correspondence Address:
Yi Feng
Department of Integrative Medicine and Neurobiology, State Key Lab of Medical Neurobiology, Institute of Acupuncture Research (WHO Collaborating Center for Traditional Medicine), Institute of Integrative Medicine, Institute of Brain Science, School of Basic Medical Sciences, Fudan University, Shanghai 200032
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2096-2924.320884

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Objective: Metabolic disorders are markedly common in women with polycystic ovary syndrome (PCOS), and nonalcoholic fatty liver disease (NAFLD) is observed in 30%–55% of all PCOS patients. Many studies have reported that autophagy and apoptosis, which are closely related to mitochondrial function, play important roles in the development of NAFLD. Therefore, in this study, we aimed to explore the role of mitochondrial dysfunction caused by liver apoptosis and autophagy imbalance in the development of NAFLD in a PCOS mouse model. Methods: We used a dihydrotestosterone (DHT)-induced PCOS model to mimic the pathological process of hyperandrogenism. Hematoxylin and eosin and Oil Red O staining assays were used to observe the pathological changes in the liver. Western blotting and quantitative real-time polymerase chain reaction were used to perform mitochondrion-related assays. Results: Hepatic steatosis and different degrees of inflammation were observed in the DHT-treated mice. The expression of molecules involved in the respiratory chain and aerobic respiration process was altered. The levels of the key molecules associated with apoptosis and autophagy were abnormal. Conclusions: Androgens may play a role in the process of hepatic steatosis development by affecting mitochondrial function and subsequently inducing apoptosis and autophagy. Such phenomena might be involved in the pathogenesis of NAFLD in women with PCOS.


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